Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3371511..3372241 Replicon chromosome
Accession NZ_CP122320
Organism Pantoea agglomerans pv. gypsophilae strain 824-1

Toxin (Protein)


Gene name higB Uniprot ID A0A356RQP5
Locus tag A7P62_RS16090 Protein ID WP_010670815.1
Coordinates 3371511..3371828 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7P62_RS16095 Protein ID WP_039391120.1
Coordinates 3371909..3372241 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P62_RS16070 (3367143) 3367143..3367265 + 123 WP_009089698.1 hypothetical protein -
A7P62_RS16075 (3367476) 3367476..3369206 + 1731 WP_064691407.1 arginine--tRNA ligase -
A7P62_RS16080 (3369293) 3369293..3370228 + 936 WP_064691408.1 LysR family transcriptional regulator -
A7P62_RS16085 (3370438) 3370438..3371436 + 999 WP_064691409.1 aldo/keto reductase -
A7P62_RS16090 (3371511) 3371511..3371828 + 318 WP_010670815.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7P62_RS16095 (3371909) 3371909..3372241 + 333 WP_039391120.1 HigA family addiction module antitoxin Antitoxin
A7P62_RS16100 (3372404) 3372404..3372796 - 393 WP_045139882.1 flagellar protein FlhE -
A7P62_RS16105 (3372796) 3372796..3374889 - 2094 WP_010258569.1 flagellar biosynthesis protein FlhA -
A7P62_RS16110 (3374882) 3374882..3376033 - 1152 WP_033772015.1 flagellar biosynthesis protein FlhB -
A7P62_RS16115 (3376222) 3376222..3376863 - 642 WP_003849160.1 protein phosphatase CheZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12284.10 Da        Isoelectric Point: 10.1171

>T276789 WP_010670815.1 NZ_CP122320:3371511-3371828 [Pantoea agglomerans pv. gypsophilae]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDIINAAISYKDLKSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR

Download         Length: 318 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12587.43 Da        Isoelectric Point: 5.1473

>AT276789 WP_039391120.1 NZ_CP122320:3371909-3372241 [Pantoea agglomerans pv. gypsophilae]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDARAQEEISRVTPLKDFLAQKENQLA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A356RQP5

Antitoxin

Source ID Structure

References