Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 970787..971480 Replicon chromosome
Accession NZ_CP122319
Organism Escherichia coli strain BW25113

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QCG47_RS04590 Protein ID WP_000415584.1
Coordinates 971184..971480 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QCG47_RS04585 Protein ID WP_000650107.1
Coordinates 970787..971182 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG47_RS04575 (966651) 966651..968909 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QCG47_RS04580 (969047) 969047..970654 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QCG47_RS04585 (970787) 970787..971182 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QCG47_RS04590 (971184) 971184..971480 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QCG47_RS04595 (971685) 971685..972167 - 483 WP_000183505.1 GyrI-like domain-containing protein -
QCG47_RS04600 (972220) 972220..972612 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QCG47_RS04605 (972764) 972764..973423 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QCG47_RS04610 (973420) 973420..974769 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QCG47_RS04615 (974815) 974815..975147 - 333 WP_000917684.1 DUF2645 family protein -
QCG47_RS04620 (975466) 975466..976047 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QCG47_RS04625 (976078) 976078..976392 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276751 WP_000415584.1 NZ_CP122319:c971480-971184 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276751 WP_000650107.1 NZ_CP122319:c971182-970787 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References