276745

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4376665..4377358 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QCG45_RS21470 Protein ID WP_000415584.1
Coordinates 4376665..4376961 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QCG45_RS21475 Protein ID WP_000650107.1
Coordinates 4376963..4377358 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS21435 (4371753) 4371753..4372067 - 315 WP_000958598.1 putative quinol monooxygenase -
QCG45_RS21440 (4372098) 4372098..4372679 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QCG45_RS21445 (4372998) 4372998..4373330 + 333 WP_000917684.1 DUF2645 family protein -
QCG45_RS21450 (4373376) 4373376..4374725 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QCG45_RS21455 (4374722) 4374722..4375381 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QCG45_RS21460 (4375533) 4375533..4375925 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QCG45_RS21465 (4375978) 4375978..4376460 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QCG45_RS21470 (4376665) 4376665..4376961 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QCG45_RS21475 (4376963) 4376963..4377358 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QCG45_RS21480 (4377491) 4377491..4379098 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QCG45_RS21485 (4379236) 4379236..4381494 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276745 WP_000415584.1 NZ_CP122318:4376665-4376961 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276745 WP_000650107.1 NZ_CP122318:4376963-4377358 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References