Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4310754..4311481 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QCG45_RS21160 Protein ID WP_000550189.1
Coordinates 4310754..4311068 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QCG45_RS21165 Protein ID WP_000560266.1
Coordinates 4311065..4311481 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS21140 (4306912) 4306912..4307898 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
QCG45_RS21145 (4307977) 4307977..4308669 - 693 WP_000942548.1 vancomycin high temperature exclusion protein -
QCG45_RS21150 (4308746) 4308746..4309249 - 504 WP_001333820.1 M48 family metallopeptidase -
QCG45_RS21155 (4309334) 4309334..4310470 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QCG45_RS21160 (4310754) 4310754..4311068 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QCG45_RS21165 (4311065) 4311065..4311481 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QCG45_RS21170 (4311526) 4311526..4313544 - 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QCG45_RS21175 (4313970) 4313970..4316321 - 2352 WP_000695487.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T276744 WP_000550189.1 NZ_CP122318:4310754-4311068 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT276744 WP_000560266.1 NZ_CP122318:4311065-4311481 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References