Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2248696..2249237 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QCG45_RS11120 Protein ID WP_000615983.1
Coordinates 2248696..2248974 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QCG45_RS11125 Protein ID WP_000729703.1
Coordinates 2248977..2249237 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS11105 (2246278) 2246278..2246856 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
QCG45_RS11110 (2247062) 2247062..2247829 + 768 WP_000333380.1 class II glutamine amidotransferase -
QCG45_RS11115 (2247800) 2247800..2248540 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QCG45_RS11120 (2248696) 2248696..2248974 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QCG45_RS11125 (2248977) 2248977..2249237 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QCG45_RS11130 (2249447) 2249447..2250196 + 750 WP_000056849.1 C40 family peptidase -
QCG45_RS11135 (2250372) 2250372..2250869 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QCG45_RS11140 (2251093) 2251093..2252805 - 1713 Protein_2170 flagellar biosynthesis protein FlhA -
QCG45_RS11145 (2252777) 2252777..2253562 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T276732 WP_000615983.1 NZ_CP122318:c2248974-2248696 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT276732 WP_000729703.1 NZ_CP122318:c2249237-2248977 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References