276723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 825777..826279 Replicon chromosome
Accession NZ_CP122318
Organism Escherichia coli strain HT873X1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QCG45_RS03900 Protein ID WP_000767829.1
Coordinates 826025..826279 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QCG45_RS03895 Protein ID WP_001259255.1
Coordinates 825777..826028 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG45_RS03870 (820955) 820955..822022 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QCG45_RS03875 (822022) 822022..823092 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QCG45_RS03880 (823089) 823089..824393 - 1305 WP_000009594.1 histidinol dehydrogenase -
QCG45_RS03885 (824399) 824399..825298 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QCG45_RS03890 (825444) 825444..825494 - 51 WP_001364200.1 his operon leader peptide -
QCG45_RS03895 (825777) 825777..826028 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QCG45_RS03900 (826025) 826025..826279 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QCG45_RS03905 (826362) 826362..827186 + 825 WP_000754737.1 SDR family oxidoreductase -
QCG45_RS03910 (827232) 827232..828161 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QCG45_RS03915 (828376) 828376..828438 + 63 WP_010723108.1 membrane protein YoeI -
QCG45_RS03920 (828428) 828428..829786 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QCG45_RS03925 (829965) 829965..831023 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
QCG45_RS03930 (831037) 831037..831264 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276723 WP_000767829.1 NZ_CP122318:826025-826279 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276723 WP_001259255.1 NZ_CP122318:825777-826028 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References