276703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3108973..3109385 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag QCG49_RS14915 Protein ID WP_000132601.1
Coordinates 3109044..3109385 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3108973..3109049 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS14905 (3105836) 3105836..3107425 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
QCG49_RS14910 (3107422) 3107422..3108816 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (3108973) 3108973..3109049 - 77 NuclAT_14 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_14 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_14 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_14 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_15 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_15 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_15 - Antitoxin
- (3108973) 3108973..3109049 - 77 NuclAT_15 - Antitoxin
QCG49_RS14915 (3109044) 3109044..3109385 + 342 WP_000132601.1 endoribonuclease SymE Toxin
QCG49_RS14920 (3109547) 3109547..3110926 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
QCG49_RS14925 (3110926) 3110926..3111972 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T276703 WP_000132601.1 NZ_CP122317:3109044-3109385 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT276703 NZ_CP122317:c3109049-3108973 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References