Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1673345..1674038 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QCG49_RS08105 Protein ID WP_000415584.1
Coordinates 1673742..1674038 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QCG49_RS08100 Protein ID WP_000650107.1
Coordinates 1673345..1673740 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS08090 (1669209) 1669209..1671467 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QCG49_RS08095 (1671605) 1671605..1673212 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QCG49_RS08100 (1673345) 1673345..1673740 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QCG49_RS08105 (1673742) 1673742..1674038 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QCG49_RS08110 (1674243) 1674243..1674725 - 483 WP_000183505.1 GyrI-like domain-containing protein -
QCG49_RS08115 (1674778) 1674778..1675170 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QCG49_RS08120 (1675322) 1675322..1675981 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QCG49_RS08125 (1675978) 1675978..1677327 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QCG49_RS08130 (1677373) 1677373..1677705 - 333 WP_000917684.1 DUF2645 family protein -
QCG49_RS08135 (1678024) 1678024..1678605 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QCG49_RS08140 (1678636) 1678636..1678950 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276699 WP_000415584.1 NZ_CP122317:c1674038-1673742 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276699 WP_000650107.1 NZ_CP122317:c1673740-1673345 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References