276694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 619946..620448 Replicon chromosome
Accession NZ_CP122317
Organism Escherichia coli strain HT-948

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QCG49_RS03160 Protein ID WP_000767829.1
Coordinates 619946..620200 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QCG49_RS03165 Protein ID WP_001259255.1
Coordinates 620197..620448 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG49_RS03130 (614961) 614961..615188 - 228 WP_000234896.1 sulfurtransferase TusA -
QCG49_RS03135 (615202) 615202..616260 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
QCG49_RS03140 (616439) 616439..617797 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QCG49_RS03145 (617787) 617787..617849 - 63 WP_010723108.1 membrane protein YoeI -
QCG49_RS03150 (618064) 618064..618993 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QCG49_RS03155 (619039) 619039..619863 - 825 WP_000754737.1 SDR family oxidoreductase -
QCG49_RS03160 (619946) 619946..620200 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QCG49_RS03165 (620197) 620197..620448 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QCG49_RS03170 (620731) 620731..620781 + 51 WP_001364200.1 his operon leader peptide -
QCG49_RS03175 (620927) 620927..621826 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QCG49_RS03180 (621832) 621832..623136 + 1305 WP_000009594.1 histidinol dehydrogenase -
QCG49_RS03185 (623133) 623133..624203 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
QCG49_RS03190 (624203) 624203..625270 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276694 WP_000767829.1 NZ_CP122317:c620200-619946 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276694 WP_001259255.1 NZ_CP122317:c620448-620197 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References