Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4344866..4345559 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QCG48_RS21335 Protein ID WP_000415584.1
Coordinates 4344866..4345162 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QCG48_RS21340 Protein ID WP_000650107.1
Coordinates 4345164..4345559 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS21300 (4339954) 4339954..4340268 - 315 WP_000958598.1 putative quinol monooxygenase -
QCG48_RS21305 (4340299) 4340299..4340880 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QCG48_RS21310 (4341199) 4341199..4341531 + 333 WP_000917684.1 DUF2645 family protein -
QCG48_RS21315 (4341577) 4341577..4342926 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QCG48_RS21320 (4342923) 4342923..4343582 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QCG48_RS21325 (4343734) 4343734..4344126 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QCG48_RS21330 (4344179) 4344179..4344661 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QCG48_RS21335 (4344866) 4344866..4345162 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QCG48_RS21340 (4345164) 4345164..4345559 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QCG48_RS21345 (4345692) 4345692..4347299 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QCG48_RS21350 (4347437) 4347437..4349695 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276683 WP_000415584.1 NZ_CP122316:4344866-4345162 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276683 WP_000650107.1 NZ_CP122316:4345164-4345559 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References