276682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4278955..4279682 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QCG48_RS21025 Protein ID WP_000550189.1
Coordinates 4278955..4279269 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QCG48_RS21030 Protein ID WP_000560266.1
Coordinates 4279266..4279682 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS21005 (4275113) 4275113..4276099 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
QCG48_RS21010 (4276178) 4276178..4276870 - 693 WP_000942548.1 vancomycin high temperature exclusion protein -
QCG48_RS21015 (4276947) 4276947..4277450 - 504 WP_001333820.1 M48 family metallopeptidase -
QCG48_RS21020 (4277535) 4277535..4278671 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QCG48_RS21025 (4278955) 4278955..4279269 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QCG48_RS21030 (4279266) 4279266..4279682 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QCG48_RS21035 (4279727) 4279727..4281745 - 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QCG48_RS21040 (4282171) 4282171..4284522 - 2352 WP_000695487.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T276682 WP_000550189.1 NZ_CP122316:4278955-4279269 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT276682 WP_000560266.1 NZ_CP122316:4279266-4279682 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References