Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4553283..4553976 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QCG46_RS22265 Protein ID WP_000415584.1
Coordinates 4553680..4553976 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QCG46_RS22260 Protein ID WP_000650107.1
Coordinates 4553283..4553678 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS22250 (4549147) 4549147..4551405 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QCG46_RS22255 (4551543) 4551543..4553150 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QCG46_RS22260 (4553283) 4553283..4553678 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QCG46_RS22265 (4553680) 4553680..4553976 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QCG46_RS22270 (4554181) 4554181..4554663 - 483 WP_000183505.1 GyrI-like domain-containing protein -
QCG46_RS22275 (4554716) 4554716..4555108 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QCG46_RS22280 (4555260) 4555260..4555919 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QCG46_RS22285 (4555916) 4555916..4557265 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QCG46_RS22290 (4557311) 4557311..4557643 - 333 WP_000917684.1 DUF2645 family protein -
QCG46_RS22295 (4557962) 4557962..4558543 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QCG46_RS22300 (4558574) 4558574..4558888 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276658 WP_000415584.1 NZ_CP122315:c4553976-4553680 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276658 WP_000650107.1 NZ_CP122315:c4553678-4553283 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References