276653

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3499886..3500388 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QCG46_RS17320 Protein ID WP_000767829.1
Coordinates 3499886..3500140 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QCG46_RS17325 Protein ID WP_001259255.1
Coordinates 3500137..3500388 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS17290 (3494901) 3494901..3495128 - 228 WP_000234896.1 sulfurtransferase TusA -
QCG46_RS17295 (3495142) 3495142..3496200 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
QCG46_RS17300 (3496379) 3496379..3497737 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QCG46_RS17305 (3497727) 3497727..3497789 - 63 WP_010723108.1 membrane protein YoeI -
QCG46_RS17310 (3498004) 3498004..3498933 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QCG46_RS17315 (3498979) 3498979..3499803 - 825 WP_000754737.1 SDR family oxidoreductase -
QCG46_RS17320 (3499886) 3499886..3500140 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QCG46_RS17325 (3500137) 3500137..3500388 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QCG46_RS17330 (3500671) 3500671..3500721 + 51 WP_001364200.1 his operon leader peptide -
QCG46_RS17335 (3500867) 3500867..3501766 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QCG46_RS17340 (3501772) 3501772..3503076 + 1305 WP_000009594.1 histidinol dehydrogenase -
QCG46_RS17345 (3503073) 3503073..3504143 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
QCG46_RS17350 (3504143) 3504143..3505210 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T276653 WP_000767829.1 NZ_CP122315:c3500140-3499886 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT276653 WP_001259255.1 NZ_CP122315:c3500388-3500137 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References