Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2076928..2077469 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QCG46_RS10090 Protein ID WP_000615983.1
Coordinates 2077191..2077469 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QCG46_RS10085 Protein ID WP_000729703.1
Coordinates 2076928..2077188 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS10065 (2072603) 2072603..2073388 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QCG46_RS10070 (2073360) 2073360..2075072 + 1713 Protein_1955 flagellar biosynthesis protein FlhA -
QCG46_RS10075 (2075296) 2075296..2075793 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QCG46_RS10080 (2075969) 2075969..2076718 - 750 WP_000056849.1 C40 family peptidase -
QCG46_RS10085 (2076928) 2076928..2077188 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QCG46_RS10090 (2077191) 2077191..2077469 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QCG46_RS10095 (2077625) 2077625..2078365 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QCG46_RS10100 (2078336) 2078336..2079103 - 768 WP_000333380.1 class II glutamine amidotransferase -
QCG46_RS10105 (2079309) 2079309..2079887 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T276635 WP_000615983.1 NZ_CP122315:2077191-2077469 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT276635 WP_000729703.1 NZ_CP122315:2076928-2077188 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References