Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 56648..57447 Replicon chromosome
Accession NZ_CP122315
Organism Escherichia coli strain HT-947

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QCG46_RS00280 Protein ID WP_000347273.1
Coordinates 56983..57447 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QCG46_RS00275 Protein ID WP_001307405.1
Coordinates 56648..56983 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG46_RS00260 (52433) 52433..53203 - 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -
QCG46_RS00265 (53219) 53219..54553 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QCG46_RS00270 (54928) 54928..56499 + 1572 WP_001273753.1 galactarate dehydratase -
QCG46_RS00275 (56648) 56648..56983 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QCG46_RS00280 (56983) 56983..57447 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QCG46_RS00285 (57502) 57502..58311 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QCG46_RS00290 (58560) 58560..59840 + 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
QCG46_RS00295 (59863) 59863..60336 + 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QCG46_RS00300 (60347) 60347..60718 + 372 Protein_58 PTS sugar transporter subunit IIC -
QCG46_RS00305 (60714) 60714..61271 + 558 Protein_59 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T276626 WP_000347273.1 NZ_CP122315:56983-57447 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT276626 WP_001307405.1 NZ_CP122315:56648-56983 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References