Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488359..4488961 Replicon chromosome
Accession NZ_CP122301
Organism Salmonella enterica strain 27A

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag P8R57_RS21800 Protein ID WP_001159635.1
Coordinates 4488650..4488961 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8R57_RS21795 Protein ID WP_000362050.1
Coordinates 4488359..4488649 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R57_RS21780 (4485852) 4485852..4486754 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
P8R57_RS21785 (4486751) 4486751..4487386 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8R57_RS21790 (4487383) 4487383..4488312 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
P8R57_RS21795 (4488359) 4488359..4488649 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8R57_RS21800 (4488650) 4488650..4488961 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8R57_RS21805 (4489179) 4489179..4490108 + 930 WP_001127705.1 alpha/beta hydrolase -
P8R57_RS21810 (4490194) 4490194..4490505 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
P8R57_RS21815 (4490502) 4490502..4490948 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
P8R57_RS21820 (4490963) 4490963..4491904 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8R57_RS21825 (4491949) 4491949..4492386 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
P8R57_RS21830 (4492383) 4492383..4493255 - 873 WP_000921423.1 virulence factor BrkB family protein -
P8R57_RS21835 (4493249) 4493249..4493848 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T276620 WP_001159635.1 NZ_CP122301:c4488961-4488650 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT276620 WP_000362050.1 NZ_CP122301:c4488649-4488359 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References