Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 2443708..2443933 | Replicon | chromosome |
| Accession | NZ_CP122301 | ||
| Organism | Salmonella enterica strain 27A | ||
Toxin (Protein)
| Gene name | hokW | Uniprot ID | S1ELB5 |
| Locus tag | P8R57_RS11880 | Protein ID | WP_000813254.1 |
| Coordinates | 2443708..2443863 (-) | Length | 52 a.a. |
Antitoxin (RNA)
| Gene name | sokW | ||
| Locus tag | - | ||
| Coordinates | 2443875..2443933 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8R57_RS11845 | 2438815..2439096 | - | 282 | WP_000445513.1 | phage holin family protein | - |
| P8R57_RS11850 | 2439086..2439274 | - | 189 | WP_001688615.1 | putative holin | - |
| P8R57_RS11855 | 2439268..2439591 | - | 324 | Protein_2321 | tellurite/colicin resistance protein | - |
| P8R57_RS11860 | 2441762..2442298 | - | 537 | WP_000640113.1 | DUF1133 family protein | - |
| P8R57_RS11865 | 2442295..2442585 | - | 291 | WP_000774470.1 | DUF1364 domain-containing protein | - |
| P8R57_RS11870 | 2442585..2443184 | - | 600 | WP_000940751.1 | DUF1367 family protein | - |
| P8R57_RS11875 | 2443247..2443417 | - | 171 | WP_000734094.1 | hypothetical protein | - |
| P8R57_RS11880 | 2443708..2443863 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | Toxin |
| - | 2443875..2443933 | + | 59 | - | - | Antitoxin |
| P8R57_RS11885 | 2444290..2445222 | + | 933 | WP_000556390.1 | hypothetical protein | - |
| P8R57_RS11890 | 2445219..2445773 | + | 555 | WP_001033796.1 | hypothetical protein | - |
| P8R57_RS11895 | 2445935..2446264 | - | 330 | WP_001676916.1 | DUF977 family protein | - |
| P8R57_RS11900 | 2446308..2446355 | - | 48 | Protein_2330 | hypothetical protein | - |
| P8R57_RS11905 | 2446537..2447004 | + | 468 | WP_001227859.1 | helix-turn-helix domain-containing protein | - |
| P8R57_RS11910 | 2447389..2447544 | + | 156 | WP_085981757.1 | DUF1391 family protein | - |
| P8R57_RS11915 | 2447652..2448173 | - | 522 | WP_000004762.1 | super-infection exclusion protein B | - |
| P8R57_RS11920 | 2448611..2448832 | + | 222 | WP_000560208.1 | cell division protein FtsZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2438273..2450144 | 11871 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 52 a.a. Molecular weight: 5736.89 Da Isoelectric Point: 6.1531
>T276608 WP_000813254.1 NZ_CP122301:c2443863-2443708 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
Download Length: 156 bp
Antitoxin
Download Length: 59 bp
>AT276608 NZ_CP122301:2443875-2443933 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
