Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1501589..1502150 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name higB Uniprot ID U4SMA9
Locus tag QBL01_RS07720 Protein ID WP_010786777.1
Coordinates 1501589..1501867 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QBL01_RS07725 Protein ID WP_005712616.1
Coordinates 1501878..1502150 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS07700 (QBL01_07700) 1497441..1498703 - 1263 WP_021113526.1 serine hydroxymethyltransferase -
QBL01_RS07705 (QBL01_07705) 1499048..1499644 + 597 WP_279378339.1 hypothetical protein -
QBL01_RS07710 (QBL01_07710) 1499735..1500076 + 342 WP_043895690.1 hypothetical protein -
QBL01_RS07715 (QBL01_07715) 1500430..1501440 - 1011 WP_279378340.1 ornithine carbamoyltransferase -
QBL01_RS07720 (QBL01_07720) 1501589..1501867 + 279 WP_010786777.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBL01_RS07725 (QBL01_07725) 1501878..1502150 + 273 WP_005712616.1 HigA family addiction module antitoxin Antitoxin
QBL01_RS07730 (QBL01_07730) 1502214..1503434 + 1221 WP_026916465.1 ATP-dependent RNA helicase RhlB -
QBL01_RS07735 (QBL01_07735) 1503444..1504931 + 1488 WP_279378341.1 DUF853 family protein -
QBL01_RS07740 (QBL01_07740) 1505084..1505626 - 543 WP_279378342.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10278.66 Da        Isoelectric Point: 10.0505

>T276568 WP_010786777.1 NZ_CP121769:1501589-1501867 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKVQN
GHAEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT276568 WP_005712616.1 NZ_CP121769:1501878-1502150 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SMA9

Antitoxin

Source ID Structure

References