Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1208554..1209197 Replicon chromosome
Accession NZ_CP121769
Organism Glaesserella parasuis strain Z44

Toxin (Protein)


Gene name higB Uniprot ID U4SMB1
Locus tag QBL01_RS05985 Protein ID WP_005714197.1
Coordinates 1208554..1208898 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBL01_RS05990 Protein ID WP_075604521.1
Coordinates 1208901..1209197 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBL01_RS05970 (QBL01_05970) 1204379..1204975 + 597 WP_021110885.1 DedA family protein -
QBL01_RS05975 (QBL01_05975) 1205158..1206249 - 1092 WP_005714201.1 murein transglycosylase A -
QBL01_RS05980 (QBL01_05980) 1206360..1208339 - 1980 WP_075604520.1 exoribonuclease II -
QBL01_RS05985 (QBL01_05985) 1208554..1208898 + 345 WP_005714197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBL01_RS05990 (QBL01_05990) 1208901..1209197 + 297 WP_075604521.1 NadS family protein Antitoxin
QBL01_RS05995 (QBL01_05995) 1209260..1210222 + 963 WP_075604522.1 WYL domain-containing protein -
QBL01_RS06000 (QBL01_06000) 1210331..1211524 + 1194 WP_075604523.1 PD-(D/E)XK nuclease family protein -
QBL01_RS06005 (QBL01_06005) 1211613..1212119 - 507 WP_075604524.1 opioid growth factor receptor-related protein -
QBL01_RS06010 (QBL01_06010) 1212355..1213098 + 744 WP_075604525.1 protein phosphatase 2C domain-containing protein -
QBL01_RS06015 (QBL01_06015) 1213109..1213819 + 711 WP_075604526.1 NAD-dependent protein deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(52-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13263.22 Da        Isoelectric Point: 5.9233

>T276566 WP_005714197.1 NZ_CP121769:1208554-1208898 [Glaesserella parasuis]
METEEYLTFIETKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11196.11 Da        Isoelectric Point: 8.8246

>AT276566 WP_075604521.1 NZ_CP121769:1208901-1209197 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPELIPVLQGI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SMB1

Antitoxin

Source ID Structure

References