Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1222845..1223488 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name higB Uniprot ID U4SMB1
Locus tag QBK97_RS05930 Protein ID WP_005714197.1
Coordinates 1223144..1223488 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QBK97_RS05925 Protein ID WP_016527809.1
Coordinates 1222845..1223141 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS05900 (QBK97_05900) 1217996..1218835 - 840 WP_279368202.1 Sir2 family NAD-dependent protein deacetylase -
QBK97_RS05905 (QBK97_05905) 1218862..1219698 - 837 WP_075630450.1 Sir2 family NAD-dependent protein deacetylase -
QBK97_RS05910 (QBK97_05910) 1219775..1220485 - 711 WP_021112440.1 NAD-dependent protein deacylase -
QBK97_RS05915 (QBK97_05915) 1220496..1221239 - 744 WP_278049264.1 protein phosphatase 2C domain-containing protein -
QBK97_RS05920 (QBK97_05920) 1221820..1222782 - 963 WP_021112452.1 WYL domain-containing protein -
QBK97_RS05925 (QBK97_05925) 1222845..1223141 - 297 WP_016527809.1 NadS family protein Antitoxin
QBK97_RS05930 (QBK97_05930) 1223144..1223488 - 345 WP_005714197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBK97_RS05935 (QBK97_05935) 1223703..1225682 + 1980 WP_160413905.1 exoribonuclease II -
QBK97_RS05940 (QBK97_05940) 1225792..1226883 + 1092 WP_005714201.1 murein transglycosylase A -
QBK97_RS05945 (QBK97_05945) 1227066..1227662 - 597 WP_021110885.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1205769..1225682 19913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(52-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13263.22 Da        Isoelectric Point: 5.9233

>T276561 WP_005714197.1 NZ_CP121768:c1223488-1223144 [Glaesserella parasuis]
METEEYLTFIETKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11196.11 Da        Isoelectric Point: 8.8246

>AT276561 WP_016527809.1 NZ_CP121768:c1223141-1222845 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPELIPVLQGL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SMB1

Antitoxin

Source ID Structure

References