Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1061733..1062294 Replicon chromosome
Accession NZ_CP121768
Organism Glaesserella parasuis strain d76

Toxin (Protein)


Gene name higB Uniprot ID A0A143CE91
Locus tag QBK97_RS05175 Protein ID WP_005712614.1
Coordinates 1062016..1062294 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QBK97_RS05170 Protein ID WP_005712616.1
Coordinates 1061733..1062005 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBK97_RS05155 (QBK97_05155) 1058256..1058798 + 543 WP_021115958.1 single-stranded DNA-binding protein -
QBK97_RS05160 (QBK97_05160) 1058952..1060439 - 1488 WP_075631110.1 DUF853 domain-containing protein -
QBK97_RS05165 (QBK97_05165) 1060449..1061669 - 1221 WP_075631111.1 ATP-dependent RNA helicase RhlB -
QBK97_RS05170 (QBK97_05170) 1061733..1062005 - 273 WP_005712616.1 HigA family addiction module antitoxin Antitoxin
QBK97_RS05175 (QBK97_05175) 1062016..1062294 - 279 WP_005712614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBK97_RS05180 (QBK97_05180) 1062443..1063453 + 1011 WP_021115969.1 ornithine carbamoyltransferase -
QBK97_RS05185 (QBK97_05185) 1063792..1067121 - 3330 WP_279368321.1 ESPR-type extended signal peptide-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10326.71 Da        Isoelectric Point: 10.0505

>T276560 WP_005712614.1 NZ_CP121768:c1062294-1062016 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKFQN
GHAEVVDYQDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT276560 WP_005712616.1 NZ_CP121768:c1062005-1061733 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CE91

Antitoxin

Source ID Structure

References