276552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5173082..5173677 Replicon chromosome
Accession NZ_CP121766
Organism Pseudomonas aeruginosa strain 22112

Toxin (Protein)


Gene name higB Uniprot ID A0A6N0KDU0
Locus tag QAY87_RS24420 Protein ID WP_023436306.1
Coordinates 5173399..5173677 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QAY87_RS24415 Protein ID WP_003133769.1
Coordinates 5173082..5173387 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAY87_RS24400 (QAY87_24395) 5169793..5170656 - 864 WP_023098850.1 integrase domain-containing protein -
QAY87_RS24405 (QAY87_24400) 5171257..5172399 - 1143 WP_023098851.1 STY4528 family pathogenicity island replication protein -
QAY87_RS24415 (QAY87_24410) 5173082..5173387 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
QAY87_RS24420 (QAY87_24415) 5173399..5173677 - 279 WP_023436306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QAY87_RS24425 (QAY87_24420) 5173730..5173858 - 129 Protein_4824 integrase -
QAY87_RS24430 (QAY87_24425) 5174006..5176234 + 2229 WP_023107900.1 TonB-dependent receptor -
QAY87_RS24435 (QAY87_24430) 5176304..5176951 - 648 WP_003095021.1 carbonate dehydratase -
QAY87_RS24440 (QAY87_24435) 5177013..5178251 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10588.11 Da        Isoelectric Point: 7.2451

>T276552 WP_023436306.1 NZ_CP121766:c5173677-5173399 [Pseudomonas aeruginosa]
MILTFRCDEARQLFETGLSRQWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT276552 WP_003133769.1 NZ_CP121766:c5173387-5173082 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N0KDU0

Antitoxin

Source ID Structure

References