Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 81483..82150 Replicon plasmid p1-WH99
Accession NZ_CP121764
Organism Prescottella equi strain WH99

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag P9990_RS25380 Protein ID WP_286462360.1
Coordinates 81483..81839 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag P9990_RS25385 Protein ID WP_231814663.1
Coordinates 81845..82150 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9990_RS25340 (P9990_25340) 77948..78079 + 132 WP_286462349.1 helix-turn-helix domain-containing protein -
P9990_RS25345 (P9990_25345) 78103..78750 + 648 WP_286462350.1 hypothetical protein -
P9990_RS25350 (P9990_25350) 78850..79158 + 309 WP_286462351.1 hypothetical protein -
P9990_RS25355 (P9990_25355) 79363..79695 + 333 WP_286462353.1 hypothetical protein -
P9990_RS25360 (P9990_25360) 79692..79871 + 180 WP_286462354.1 hypothetical protein -
P9990_RS25365 (P9990_25365) 79960..80331 + 372 WP_286462355.1 helix-turn-helix transcriptional regulator -
P9990_RS25370 (P9990_25370) 80495..80788 + 294 WP_286462356.1 hypothetical protein -
P9990_RS25375 (P9990_25375) 80890..81417 + 528 WP_286462359.1 DnaB-like helicase N-terminal domain-containing protein -
P9990_RS25380 (P9990_25380) 81483..81839 + 357 WP_286462360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9990_RS25385 (P9990_25385) 81845..82150 + 306 WP_231814663.1 XRE family transcriptional regulator Antitoxin
P9990_RS25390 (P9990_25390) 82303..82851 - 549 WP_286462362.1 DUF6226 family protein -
P9990_RS25395 (P9990_25395) 83069..83383 + 315 Protein_92 hypothetical protein -
P9990_RS25400 (P9990_25400) 83621..83962 - 342 WP_286462363.1 hypothetical protein -
P9990_RS25405 (P9990_25405) 84046..84222 - 177 WP_286462505.1 hypothetical protein -
P9990_RS25410 (P9990_25410) 84807..85280 - 474 WP_286462364.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(46) - 1..431692 431692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(30-92)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13717.53 Da        Isoelectric Point: 4.8382

>T276546 WP_286462360.1 NZ_CP121764:81483-81839 [Prescottella equi]
VTNWDVDLELIEDWLTELDQESYEQVVAALELLQERGPQLGRPLVDTIKASRHKNMKELRPGSSGRSELRVLFAFDPERK
AIFLVAGDKAGRWEKWYKVNIPIADDRFDDHLRQLEGK

Download         Length: 357 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11541.16 Da        Isoelectric Point: 8.5833

>AT276546 WP_231814663.1 NZ_CP121764:81845-82150 [Prescottella equi]
MAKSLDDMLAKRPVDRAAVDTHKARMLEQVRAYRLQELREARELTQQQVADRLGVKQNRVSNIERGDLANVQLDTLRRYV
DAVGGTLRIEVELGDDRIQIA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References