276542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4129509..4130157 Replicon chromosome
Accession NZ_CP121700
Organism Methylobacterium indicum strain JDJ13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QBE04_RS19030 Protein ID WP_279356470.1
Coordinates 4129509..4129790 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0J6RZH8
Locus tag QBE04_RS19035 Protein ID WP_048431112.1
Coordinates 4129837..4130157 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBE04_RS19000 4124619..4125053 + 435 WP_279356466.1 CU044_2847 family protein -
QBE04_RS19005 4125196..4126506 + 1311 WP_279356467.1 adenylosuccinate lyase -
QBE04_RS19010 4126727..4127056 + 330 WP_048431117.1 type II toxin-antitoxin system RelE/ParE family toxin -
QBE04_RS19015 4127046..4127327 + 282 WP_048431116.1 XRE family transcriptional regulator -
QBE04_RS19020 4127338..4128264 - 927 WP_279356468.1 dihydrodipicolinate synthase family protein -
QBE04_RS19025 4128462..4129313 + 852 WP_279356469.1 D-amino-acid transaminase -
QBE04_RS19030 4129509..4129790 + 282 WP_279356470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QBE04_RS19035 4129837..4130157 + 321 WP_048431112.1 HigA family addiction module antitoxin Antitoxin
QBE04_RS19040 4130225..4130587 + 363 WP_048431111.1 hypothetical protein -
QBE04_RS19045 4130749..4132041 + 1293 WP_279356471.1 adenylosuccinate synthase -
QBE04_RS19050 4132115..4133449 + 1335 WP_279356472.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10696.25 Da        Isoelectric Point: 9.7576

>T276542 WP_279356470.1 NZ_CP121700:4129509-4129790 [Methylobacterium indicum]
VIRSFADERTRHVFEGRHPKGIPADILKTARRKLDYLDAATSLDALKVPPGNKLHPLLRARAGQHAIRINDQFRVCFRWT
EIGPEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11946.78 Da        Isoelectric Point: 5.1649

>AT276542 WP_048431112.1 NZ_CP121700:4129837-4130157 [Methylobacterium indicum]
MSTEYESDTVLPPMHPGEVLREEFMVPLNLTAYAIAKACRVPRTRIERIAREEIGITADTALRLGRYFGMDPQVWVNLQS
RFDLLTARAAIGAAMDDIRPLQREAA

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J6RZH8

References