Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4437102..4437802 Replicon chromosome
Accession NZ_CP121682
Organism Streptomyces sp. HUAS 5

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag PYS65_RS20345 Protein ID WP_279335353.1
Coordinates 4437404..4437802 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag PYS65_RS20340 Protein ID WP_279335352.1
Coordinates 4437102..4437392 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYS65_RS20320 (PYS65_20320) 4432267..4433388 + 1122 WP_279335348.1 peptidoglycan bridge formation glycyltransferase FemA/FemB family protein -
PYS65_RS20325 (PYS65_20325) 4433720..4435303 - 1584 WP_279335349.1 von Willebrand factor type A domain-containing protein -
PYS65_RS20330 (PYS65_20330) 4435678..4436646 + 969 WP_279335350.1 EamA family transporter -
PYS65_RS20335 (PYS65_20335) 4436693..4437052 + 360 WP_279335351.1 DUF6247 family protein -
PYS65_RS20340 (PYS65_20340) 4437102..4437392 - 291 WP_279335352.1 helix-turn-helix transcriptional regulator Antitoxin
PYS65_RS20345 (PYS65_20345) 4437404..4437802 - 399 WP_279335353.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYS65_RS20350 (PYS65_20350) 4437940..4438737 + 798 WP_279335354.1 TIGR03084 family metal-binding protein -
PYS65_RS20355 (PYS65_20355) 4438734..4440434 + 1701 WP_279335355.1 DUF1446 domain-containing protein -
PYS65_RS20360 (PYS65_20360) 4440431..4442029 + 1599 WP_279335356.1 carboxyl transferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-115)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-80)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15167.36 Da        Isoelectric Point: 9.7528

>T276531 WP_279335353.1 NZ_CP121682:c4437802-4437404 [Streptomyces sp. HUAS 5]
VAEPYELRFFDDVLNWIKTLAKEDPDSHLHVIAALERLQEVGPALRRPTVGAIEKSRYRNMRELRPRNGGAVSIRMLFVF
DPERRAIFLVAGNKAAGRQWAAWYPRAVKEADDKFTAYLEALEQEKKKGQGE

Download         Length: 399 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10381.85 Da        Isoelectric Point: 6.4671

>AT276531 WP_279335352.1 NZ_CP121682:c4437392-4437102 [Streptomyces sp. HUAS 5]
MDDLTADITPEKRERIDAIKAEMVDAERGHELATLRKAQGFTQIQVAKAMGVTQGRVSQIERGTARLDTSTMAAYLHAIG
GELTITATVGNLSVRL

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References