Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1984772..1985354 Replicon chromosome
Accession NZ_CP121679
Organism Ancylobacter sp. WKF20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AncyloWKF20_RS09220 Protein ID WP_279317558.1
Coordinates 1985073..1985354 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AncyloWKF20_RS09215 Protein ID WP_279317557.1
Coordinates 1984772..1985062 (-) Length 97 a.a.

Genomic Context

AncyloWKF20_RS09195AncyloWKF20_RS09210AncyloWKF20_RS09245AncyloWKF20_RS09200AncyloWKF20_RS09205AncyloWKF20_RS09215AncyloWKF20_RS09220AncyloWKF20_RS09225AncyloWKF20_RS09230AncyloWKF20_RS09235AncyloWKF20_RS09240
Location: 1980617..1981072 (456 bp)
Type: Others
Protein ID: WP_279317553.1
Location: 1982903..1984765 (1863 bp)
Type: Others
Protein ID: WP_279317556.1
Location: 1988498..1989508 (1011 bp)
Type: Others
Protein ID: WP_279317562.1
Location: 1981080..1982012 (933 bp)
Type: Others
Protein ID: WP_279317554.1
Location: 1982076..1982771 (696 bp)
Type: Others
Protein ID: WP_279317555.1
Location: 1984772..1985062 (291 bp)
Type: Antitoxin
Protein ID: WP_279317557.1
Location: 1985073..1985354 (282 bp)
Type: Toxin
Protein ID: WP_279317558.1
Location: 1985415..1986626 (1212 bp)
Type: Others
Protein ID: WP_279317559.1
Location: 1986623..1986883 (261 bp)
Type: Others
Protein ID: WP_279317560.1
Location: 1986883..1987551 (669 bp)
Type: Others
Protein ID: WP_279317920.1
Location: 1987581..1988237 (657 bp)
Type: Others
Protein ID: WP_279317561.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AncyloWKF20_RS09195 (AncyloWKF20_09195)1980617..1981072+456WP_279317553.1tRNA (cytidine(34)-2'-O)-methyltransferase-
AncyloWKF20_RS09200 (AncyloWKF20_09200)1981080..1982012-933WP_279317554.1oxygen-dependent coproporphyrinogen oxidase-
AncyloWKF20_RS09205 (AncyloWKF20_09205)1982076..1982771-696WP_279317555.1VIT family protein-
AncyloWKF20_RS09210 (AncyloWKF20_09210)1982903..1984765+1863WP_279317556.1ABC transporter ATP-binding protein-
AncyloWKF20_RS09215 (AncyloWKF20_09215)1984772..1985062-291WP_279317557.1HigA family addiction module antitoxinAntitoxin
AncyloWKF20_RS09220 (AncyloWKF20_09220)1985073..1985354-282WP_279317558.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AncyloWKF20_RS09225 (AncyloWKF20_09225)1985415..1986626-1212WP_279317559.1CCA tRNA nucleotidyltransferase-
AncyloWKF20_RS09230 (AncyloWKF20_09230)1986623..1986883-261WP_279317560.1DUF6111 family protein-
AncyloWKF20_RS09235 (AncyloWKF20_09235)1986883..1987551-669WP_279317920.1CoA pyrophosphatase-
AncyloWKF20_RS09240 (AncyloWKF20_09240)1987581..1988237-657WP_279317561.1DUF1285 domain-containing protein-
AncyloWKF20_RS09245 (AncyloWKF20_09245)1988498..1989508+1011WP_279317562.1MoxR family ATPase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10420.00 Da        Isoelectric Point: 10.4492

>T276527 WP_279317558.1 NZ_CP121679:c1985354-1985073 [Ancylobacter sp. WKF20]
MILNFRDKRTAAVWAGQVGKGFPADLVRGAQRKLAMIHAAVTLDALRAPPANRLEVLKGDRAGQHSIRINDQFRICFIWR
DGHAADVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.10 Da        Isoelectric Point: 7.2015

>AT276527 WP_279317557.1 NZ_CP121679:c1985062-1984772 [Ancylobacter sp. WKF20]
MIGPNPPIHPGEVLREEFLAPMGLKPYGLAKALHVPRTRIERLAREEAPVTADTALRLGRYFGTGPEFWMNLQSAYDLAI
TVAAAPDIAAITPRAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References