Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1984772..1985354 Replicon chromosome
Accession NZ_CP121679
Organism Ancylobacter sp. WKF20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AncyloWKF20_RS09220 Protein ID WP_279317558.1
Coordinates 1985073..1985354 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AncyloWKF20_RS09215 Protein ID WP_279317557.1
Coordinates 1984772..1985062 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AncyloWKF20_RS09195 (AncyloWKF20_09195) 1980617..1981072 + 456 WP_279317553.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
AncyloWKF20_RS09200 (AncyloWKF20_09200) 1981080..1982012 - 933 WP_279317554.1 oxygen-dependent coproporphyrinogen oxidase -
AncyloWKF20_RS09205 (AncyloWKF20_09205) 1982076..1982771 - 696 WP_279317555.1 VIT family protein -
AncyloWKF20_RS09210 (AncyloWKF20_09210) 1982903..1984765 + 1863 WP_279317556.1 ABC transporter ATP-binding protein -
AncyloWKF20_RS09215 (AncyloWKF20_09215) 1984772..1985062 - 291 WP_279317557.1 HigA family addiction module antitoxin Antitoxin
AncyloWKF20_RS09220 (AncyloWKF20_09220) 1985073..1985354 - 282 WP_279317558.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AncyloWKF20_RS09225 (AncyloWKF20_09225) 1985415..1986626 - 1212 WP_279317559.1 CCA tRNA nucleotidyltransferase -
AncyloWKF20_RS09230 (AncyloWKF20_09230) 1986623..1986883 - 261 WP_279317560.1 DUF6111 family protein -
AncyloWKF20_RS09235 (AncyloWKF20_09235) 1986883..1987551 - 669 WP_279317920.1 CoA pyrophosphatase -
AncyloWKF20_RS09240 (AncyloWKF20_09240) 1987581..1988237 - 657 WP_279317561.1 DUF1285 domain-containing protein -
AncyloWKF20_RS09245 (AncyloWKF20_09245) 1988498..1989508 + 1011 WP_279317562.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10420.00 Da        Isoelectric Point: 10.4492

>T276527 WP_279317558.1 NZ_CP121679:c1985354-1985073 [Ancylobacter sp. WKF20]
MILNFRDKRTAAVWAGQVGKGFPADLVRGAQRKLAMIHAAVTLDALRAPPANRLEVLKGDRAGQHSIRINDQFRICFIWR
DGHAADVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.10 Da        Isoelectric Point: 7.2015

>AT276527 WP_279317557.1 NZ_CP121679:c1985062-1984772 [Ancylobacter sp. WKF20]
MIGPNPPIHPGEVLREEFLAPMGLKPYGLAKALHVPRTRIERLAREEAPVTADTALRLGRYFGTGPEFWMNLQSAYDLAI
TVAAAPDIAAITPRAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References