Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6815244..6815830 Replicon chromosome
Accession NZ_CP121648
Organism Methylobacterium nodulans strain CB376

Toxin (Protein)


Gene name higB Uniprot ID B0UR34
Locus tag QA634_RS31415 Protein ID WP_012335864.1
Coordinates 6815549..6815830 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QA634_RS31410 Protein ID WP_018263550.1
Coordinates 6815244..6815534 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA634_RS31390 (QA634_31390) 6810512..6811036 + 525 WP_012335859.1 histidine phosphatase family protein -
QA634_RS31395 (QA634_31395) 6811305..6812660 + 1356 WP_012335860.1 hypothetical protein -
QA634_RS31400 (QA634_31400) 6812781..6814226 + 1446 WP_012335861.1 YcjX family protein -
QA634_RS31405 (QA634_31405) 6814223..6815233 + 1011 WP_012335862.1 TIGR01620 family protein -
QA634_RS31410 (QA634_31410) 6815244..6815534 - 291 WP_018263550.1 HigA family addiction module antitoxin Antitoxin
QA634_RS31415 (QA634_31415) 6815549..6815830 - 282 WP_012335864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QA634_RS31420 (QA634_31420) 6816064..6817236 - 1173 WP_012335865.1 4-hydroxybenzoate 3-monooxygenase -
QA634_RS31425 (QA634_31425) 6817399..6818286 + 888 WP_012335866.1 helix-turn-helix domain-containing protein -
QA634_RS31430 (QA634_31430) 6818292..6819200 + 909 WP_012335867.1 aldo/keto reductase -
QA634_RS31435 (QA634_31435) 6819460..6819864 + 405 WP_012335868.1 hypothetical protein -
QA634_RS31440 (QA634_31440) 6819898..6820389 - 492 WP_012335869.1 tRNA (cytidine(34)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.15 Da        Isoelectric Point: 6.3228

>T276487 WP_012335864.1 NZ_CP121648:c6815830-6815549 [Methylobacterium nodulans]
MIQSFADKHARALHEDGICHPRWRAFERIALRKLDALDAAVDLDDLRSPPGNRLEPLQGDRAGQHSIRINDQWRICFRWT
DLGPEEVAIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10910.44 Da        Isoelectric Point: 10.4025

>AT276487 WP_018263550.1 NZ_CP121648:c6815534-6815244 [Methylobacterium nodulans]
MPRIRTHPGEVLLEDFMKPFGLSARQLAEAIRVPHNRIGDILRERRSITADTALRLGRYFGTTAQFWVNLQTAHDLSKAA
ATHDYETIRPREAAPT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0UR34

Antitoxin

Source ID Structure

References