Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10986..11637 Replicon plasmid pIII_JAB186
Accession NZ_CP121611
Organism Acinetobacter baumannii strain JAB186

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MTS34_RS20155 Protein ID WP_000269902.1
Coordinates 10986..11342 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTS34_RS20160 Protein ID WP_001140622.1
Coordinates 11335..11637 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS34_RS20130 (MTS34_20130) 6498..6641 - 144 WP_001125246.1 hypothetical protein -
MTS34_RS20135 (MTS34_20135) 6661..7236 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS34_RS20140 (MTS34_20140) 7229..8179 - 951 WP_001205343.1 replication initiation protein RepM -
MTS34_RS20145 (MTS34_20145) 9315..9506 + 192 WP_000032259.1 hypothetical protein -
MTS34_RS20150 (MTS34_20150) 9550..10377 - 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
MTS34_RS20155 (MTS34_20155) 10986..11342 + 357 WP_000269902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTS34_RS20160 (MTS34_20160) 11335..11637 + 303 WP_001140622.1 XRE family transcriptional regulator Antitoxin
MTS34_RS20165 (MTS34_20165) 11630..11839 + 210 WP_000069473.1 hypothetical protein -
MTS34_RS20170 (MTS34_20170) 12165..12626 - 462 WP_000761346.1 DIP1984 family protein -
MTS34_RS20175 (MTS34_20175) 12931..15345 - 2415 Protein_17 TonB-dependent receptor ZnuD2 -
MTS34_RS20180 (MTS34_20180) 15473..15787 - 315 WP_001983304.1 BrnA antitoxin family protein -
MTS34_RS20185 (MTS34_20185) 15774..16061 - 288 WP_000438826.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / blaOXA-72 - 1..21454 21454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T276449 WP_000269902.1 NZ_CP121611:10986-11342 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT276449 WP_001140622.1 NZ_CP121611:11335-11637 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References