276448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4727..5312 Replicon plasmid pIII_JAB186
Accession NZ_CP121611
Organism Acinetobacter baumannii strain JAB186

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag MTS34_RS20120 Protein ID WP_000897307.1
Coordinates 4992..5312 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTS34_RS20115 Protein ID WP_000369781.1
Coordinates 4727..4999 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS34_RS20090 (MTS34_20090) 154..411 + 258 WP_159516864.1 hypothetical protein -
MTS34_RS20095 (MTS34_20095) 443..823 - 381 WP_015060210.1 hypothetical protein -
MTS34_RS20100 (MTS34_20100) 1018..1629 + 612 WP_015060246.1 recombinase family protein -
MTS34_RS20105 (MTS34_20105) 1819..2703 - 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
MTS34_RS20110 (MTS34_20110) 2759..4234 - 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
MTS34_RS20115 (MTS34_20115) 4727..4999 - 273 WP_000369781.1 NadS family protein Antitoxin
MTS34_RS20120 (MTS34_20120) 4992..5312 - 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTS34_RS20125 (MTS34_20125) 5488..6315 + 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
MTS34_RS20130 (MTS34_20130) 6498..6641 - 144 WP_001125246.1 hypothetical protein -
MTS34_RS20135 (MTS34_20135) 6661..7236 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
MTS34_RS20140 (MTS34_20140) 7229..8179 - 951 WP_001205343.1 replication initiation protein RepM -
MTS34_RS20145 (MTS34_20145) 9315..9506 + 192 WP_000032259.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / blaOXA-72 - 1..21454 21454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T276448 WP_000897307.1 NZ_CP121611:c5312-4992 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT276448 WP_000369781.1 NZ_CP121611:c4999-4727 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3

Antitoxin

Source ID Structure

References