Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26052..26710 Replicon plasmid pIV_RAB77
Accession NZ_CP121599
Organism Acinetobacter baumannii strain JAB77

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MTS78_RS19625 Protein ID WP_000312250.1
Coordinates 26052..26411 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTS78_RS19630 Protein ID WP_001096429.1
Coordinates 26411..26710 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS78_RS19590 (MTS78_19590) 21129..21443 - 315 WP_000708714.1 hypothetical protein -
MTS78_RS19595 (MTS78_19595) 22498..22794 - 297 WP_000253575.1 hypothetical protein -
MTS78_RS19600 (MTS78_19600) 23197..23700 - 504 WP_001053125.1 hypothetical protein -
MTS78_RS19605 (MTS78_19605) 23767..24150 - 384 WP_000654348.1 hypothetical protein -
MTS78_RS19610 (MTS78_19610) 24289..24987 - 699 WP_000873188.1 hypothetical protein -
MTS78_RS19615 (MTS78_19615) 25054..25236 - 183 WP_000373385.1 hypothetical protein -
MTS78_RS19620 (MTS78_19620) 25285..25851 - 567 WP_000710385.1 hypothetical protein -
MTS78_RS19625 (MTS78_19625) 26052..26411 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTS78_RS19630 (MTS78_19630) 26411..26710 + 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
MTS78_RS19635 (MTS78_19635) 27248..27784 - 537 WP_000731978.1 hypothetical protein -
MTS78_RS19640 (MTS78_19640) 27834..28388 - 555 WP_000790084.1 hypothetical protein -
MTS78_RS19645 (MTS78_19645) 28408..28626 - 219 WP_001043201.1 hypothetical protein -
MTS78_RS19650 (MTS78_19650) 28666..29295 - 630 WP_000701003.1 hypothetical protein -
MTS78_RS19655 (MTS78_19655) 29312..29491 - 180 WP_000387630.1 hypothetical protein -
MTS78_RS19660 (MTS78_19660) 29467..29832 - 366 WP_079757771.1 hypothetical protein -
MTS78_RS19665 (MTS78_19665) 30067..31035 - 969 WP_005804963.1 IS30 family transposase -
MTS78_RS19670 (MTS78_19670) 31130..31390 - 261 WP_283026619.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa - 1..72243 72243
- flank IS/Tn - - 30067..31092 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-109)

Antitoxin

(12-88)


Sequences


Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T276445 WP_000312250.1 NZ_CP121599:26052-26411 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp


Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT276445 WP_001096429.1 NZ_CP121599:26411-26710 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References