Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 61466..62124 Replicon plasmid pIV_MAB17
Accession NZ_CP121596
Organism Acinetobacter baumannii strain MAB17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MTS72_RS19335 Protein ID WP_000312250.1
Coordinates 61466..61825 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTS72_RS19340 Protein ID WP_001096429.1
Coordinates 61825..62124 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS72_RS19305 (MTS72_19305) 56987..57301 - 315 WP_000708714.1 hypothetical protein -
MTS72_RS19310 (MTS72_19310) 58356..59114 - 759 WP_001053127.1 hypothetical protein -
MTS72_RS19315 (MTS72_19315) 59181..59564 - 384 WP_000654348.1 hypothetical protein -
MTS72_RS19320 (MTS72_19320) 59703..60401 - 699 WP_000873188.1 hypothetical protein -
MTS72_RS19325 (MTS72_19325) 60468..60650 - 183 WP_000373385.1 hypothetical protein -
MTS72_RS19330 (MTS72_19330) 60699..61265 - 567 WP_000710385.1 hypothetical protein -
MTS72_RS19335 (MTS72_19335) 61466..61825 + 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTS72_RS19340 (MTS72_19340) 61825..62124 + 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
MTS72_RS19345 (MTS72_19345) 62662..63198 - 537 WP_000731978.1 hypothetical protein -
MTS72_RS19350 (MTS72_19350) 63248..63802 - 555 WP_000790084.1 hypothetical protein -
MTS72_RS19355 (MTS72_19355) 63822..64040 - 219 WP_001043201.1 hypothetical protein -
MTS72_RS19360 (MTS72_19360) 64080..64709 - 630 WP_000701003.1 hypothetical protein -
MTS72_RS19365 (MTS72_19365) 64726..64905 - 180 WP_000387630.1 hypothetical protein -
MTS72_RS19370 (MTS72_19370) 64881..65453 - 573 WP_000443897.1 hypothetical protein -
MTS72_RS19375 (MTS72_19375) 65458..65715 - 258 WP_000834290.1 hypothetical protein -
MTS72_RS19380 (MTS72_19380) 65820..67100 - 1281 WP_001093570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa - 1..70544 70544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T276442 WP_000312250.1 NZ_CP121596:61466-61825 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT276442 WP_001096429.1 NZ_CP121596:61825-62124 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References