Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4816122..4816726 Replicon chromosome
Accession NZ_CP121476
Organism Pseudomonas sp. 905_Psudmo1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P9K38_RS22615 Protein ID WP_021488744.1
Coordinates 4816412..4816726 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A328VUT6
Locus tag P9K38_RS22610 Protein ID WP_021488745.1
Coordinates 4816122..4816412 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9K38_RS22590 (P9K38_22590) 4811625..4812488 - 864 WP_010466255.1 phosphate/phosphite/phosphonate ABC transporter substrate-binding protein -
P9K38_RS22595 (P9K38_22595) 4812485..4813312 - 828 WP_003118432.1 phosphonate ABC transporter ATP-binding protein -
P9K38_RS22600 (P9K38_22600) 4813637..4813810 - 174 WP_230927756.1 AlpA family phage regulatory protein -
P9K38_RS22605 (P9K38_22605) 4814062..4815525 - 1464 WP_021488746.1 hypothetical protein -
P9K38_RS22610 (P9K38_22610) 4816122..4816412 - 291 WP_021488745.1 helix-turn-helix domain-containing protein Antitoxin
P9K38_RS22615 (P9K38_22615) 4816412..4816726 - 315 WP_021488744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9K38_RS22620 (P9K38_22620) 4817256..4818026 + 771 WP_021488743.1 NERD domain-containing protein -
P9K38_RS22625 (P9K38_22625) 4818101..4819519 + 1419 WP_021488742.1 hypothetical protein -
P9K38_RS22630 (P9K38_22630) 4819663..4820304 + 642 WP_278325558.1 GIY-YIG nuclease family protein -
P9K38_RS22635 (P9K38_22635) 4820404..4820670 - 267 WP_021490327.1 helix-turn-helix transcriptional regulator -
P9K38_RS22640 (P9K38_22640) 4820766..4821293 + 528 WP_021490328.1 Bro-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11888.76 Da        Isoelectric Point: 9.7334

>T276354 WP_021488744.1 NZ_CP121476:c4816726-4816412 [Pseudomonas sp. 905_Psudmo1]
MIFIETPIFTEDVKELLSEDEYREFQQYLADNPLAGRVITETGGLRKVRWGSAGRGKSGGVRVIYFHVVGASQIRLVMIY
QKGIKDDLSKDEKKALRKIIEGWK

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10792.33 Da        Isoelectric Point: 10.9144

>AT276354 WP_021488745.1 NZ_CP121476:c4816412-4816122 [Pseudomonas sp. 905_Psudmo1]
MEKNLFNRLLESTVQMDEIARGERQPSREFHVDAAQVRIIRKRTGMAQPAFAEAIGVALGTLRNWEQGRRDPEGPAKALL
RAISNDPQNVIAALRQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A328VUT6

References