Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2621836..2622406 Replicon chromosome
Accession NZ_CP121463
Organism Arthrobacter sp. Y-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P9849_RS11795 Protein ID WP_278266971.1
Coordinates 2622125..2622406 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P9849_RS11790 Protein ID WP_278266970.1
Coordinates 2621836..2622138 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9849_RS11770 (P9849_11770) 2617676..2618911 - 1236 WP_278266966.1 alpha/beta fold hydrolase -
P9849_RS11775 (P9849_11775) 2618977..2619915 - 939 WP_278266967.1 DMT family transporter -
P9849_RS11780 (P9849_11780) 2619988..2620893 + 906 WP_278266968.1 LysR family transcriptional regulator -
P9849_RS11785 (P9849_11785) 2620972..2621802 + 831 WP_278266969.1 oxidoreductase -
P9849_RS11790 (P9849_11790) 2621836..2622138 - 303 WP_278266970.1 HigA family addiction module antitoxin Antitoxin
P9849_RS11795 (P9849_11795) 2622125..2622406 - 282 WP_278266971.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9849_RS11800 (P9849_11800) 2622679..2623215 - 537 WP_278266972.1 hypothetical protein -
P9849_RS11805 (P9849_11805) 2623278..2624006 - 729 WP_278266973.1 hypothetical protein -
P9849_RS11810 (P9849_11810) 2624191..2625054 - 864 WP_278266974.1 AraC family transcriptional regulator -
P9849_RS11815 (P9849_11815) 2625302..2625640 - 339 WP_278266975.1 DUF86 domain-containing protein -
P9849_RS11820 (P9849_11820) 2625637..2626080 - 444 WP_278266976.1 helix-turn-helix domain-containing protein -
P9849_RS11825 (P9849_11825) 2626164..2626613 - 450 WP_278266977.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10766.23 Da        Isoelectric Point: 11.0062

>T276343 WP_278266971.1 NZ_CP121463:c2622406-2622125 [Arthrobacter sp. Y-9]
VIRSFRDPATGRLWRRDRVPSIDSRIHRVALRKLRQLGAAESLADLRVPPGNRLEALAGERAGQHSIRINDQWRICFRWT
DAGPEEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11231.02 Da        Isoelectric Point: 7.3186

>AT276343 WP_278266970.1 NZ_CP121463:c2622138-2621836 [Arthrobacter sp. Y-9]
MTITERLAPVHPGEVLLADFIEAFGITQNKLAVSIKVPPRRINEIVHGKRAITADTALRLARYFGTTPQFWLHLQIQYEL
DRAEDRVAGQIAEITPLQVA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References