Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 27681..28332 Replicon plasmid plas1_LRB
Accession NZ_CP121371
Organism Acinetobacter baumannii strain LRB

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag P9J61_RS18360 Protein ID WP_000269904.1
Coordinates 27681..28037 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P9J61_RS18365 Protein ID WP_024436604.1
Coordinates 28030..28332 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J61_RS18340 (P9J61_18340) 23428..23763 - 336 WP_004740263.1 carboxymuconolactone decarboxylase family protein -
P9J61_RS18345 (P9J61_18345) 23961..24068 - 108 Protein_24 transcriptional regulator -
P9J61_RS18350 (P9J61_18350) 24110..24796 - 687 WP_004740261.1 DUF4145 domain-containing protein -
P9J61_RS18355 (P9J61_18355) 24910..26964 - 2055 WP_004740259.1 TonB-dependent receptor -
P9J61_RS18360 (P9J61_18360) 27681..28037 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9J61_RS18365 (P9J61_18365) 28030..28332 + 303 WP_024436604.1 XRE family transcriptional regulator Antitoxin
P9J61_RS18370 (P9J61_18370) 28325..28534 + 210 WP_000069475.1 hypothetical protein -
P9J61_RS18375 (P9J61_18375) 28709..29227 + 519 WP_000447196.1 tetratricopeptide repeat protein -
P9J61_RS18380 (P9J61_18380) 29266..29778 + 513 WP_024436968.1 SMI1/KNR4 family protein -
P9J61_RS18385 (P9J61_18385) 29961..30296 + 336 Protein_32 hypothetical protein -
P9J61_RS18390 (P9J61_18390) 30359..31524 + 1166 WP_085942227.1 IS3-like element ISAba22 family transposase -
P9J61_RS18395 (P9J61_18395) 31891..32118 - 228 Protein_34 recombinase family protein -
P9J61_RS18400 (P9J61_18400) 32173..32877 - 705 WP_004741406.1 IS6-like element IS1006 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101824 101824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T276333 WP_000269904.1 NZ_CP121371:27681-28037 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11181.00 Da        Isoelectric Point: 7.3198

>AT276333 WP_024436604.1 NZ_CP121371:28030-28332 [Acinetobacter baumannii]
MAKSLQELLASRSPESQTRIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References