Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 74139..74790 Replicon plasmid plas1_Ab_8_4
Accession NZ_CP121366
Organism Acinetobacter baumannii strain Ab_8_4

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag P9J59_RS18625 Protein ID WP_000269904.1
Coordinates 74434..74790 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P9J59_RS18620 Protein ID WP_024436604.1
Coordinates 74139..74441 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J59_RS18585 (P9J59_18585) 69594..70298 + 705 WP_004741406.1 IS6-like element IS1006 family transposase -
P9J59_RS18590 (P9J59_18590) 70353..70580 + 228 Protein_72 recombinase family protein -
P9J59_RS18600 (P9J59_18600) 72175..72510 - 336 Protein_74 hypothetical protein -
P9J59_RS18605 (P9J59_18605) 72693..73205 - 513 WP_024436968.1 SMI1/KNR4 family protein -
P9J59_RS18610 (P9J59_18610) 73244..73762 - 519 WP_000447196.1 tetratricopeptide repeat protein -
P9J59_RS18615 (P9J59_18615) 73937..74146 - 210 WP_000069475.1 hypothetical protein -
P9J59_RS18620 (P9J59_18620) 74139..74441 - 303 WP_024436604.1 XRE family transcriptional regulator Antitoxin
P9J59_RS18625 (P9J59_18625) 74434..74790 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9J59_RS18630 (P9J59_18630) 75507..77561 + 2055 WP_004740259.1 TonB-dependent receptor -
P9J59_RS18635 (P9J59_18635) 77675..78361 + 687 WP_004740261.1 DUF4145 domain-containing protein -
P9J59_RS18640 (P9J59_18640) 78403..78510 + 108 Protein_82 transcriptional regulator -
P9J59_RS18645 (P9J59_18645) 78708..79043 + 336 WP_004740263.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101824 101824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T276326 WP_000269904.1 NZ_CP121366:c74790-74434 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11181.00 Da        Isoelectric Point: 7.3198

>AT276326 WP_024436604.1 NZ_CP121366:c74441-74139 [Acinetobacter baumannii]
MAKSLQELLASRSPESQTRIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References