Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 730602..731295 Replicon chromosome
Accession NZ_CP121356
Organism Escherichia coli strain rl0044

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag P9060_RS03580 Protein ID WP_000415584.1
Coordinates 730602..730898 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag P9060_RS03585 Protein ID WP_000650107.1
Coordinates 730900..731295 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9060_RS03545 (725690) 725690..726004 - 315 WP_000958598.1 putative quinol monooxygenase -
P9060_RS03550 (726035) 726035..726616 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
P9060_RS03555 (726935) 726935..727267 + 333 WP_000917684.1 DUF2645 family protein -
P9060_RS03560 (727313) 727313..728662 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
P9060_RS03565 (728659) 728659..729318 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
P9060_RS03570 (729470) 729470..729862 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
P9060_RS03575 (729915) 729915..730397 + 483 WP_000183505.1 GyrI-like domain-containing protein -
P9060_RS03580 (730602) 730602..730898 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
P9060_RS03585 (730900) 730900..731295 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
P9060_RS03590 (731428) 731428..733035 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
P9060_RS03595 (733173) 733173..735431 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T276294 WP_000415584.1 NZ_CP121356:730602-730898 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT276294 WP_000650107.1 NZ_CP121356:730900-731295 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References