Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1178073..1178685 Replicon chromosome
Accession NZ_CP121355
Organism Mesorhizobium sp. WSM4906

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QAZ22_RS05615 Protein ID WP_278206015.1
Coordinates 1178073..1178369 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QAZ22_RS05620 Protein ID WP_278206016.1
Coordinates 1178377..1178685 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAZ22_RS05590 (QAZ22_05590) 1174285..1175058 + 774 WP_278206011.1 FadR/GntR family transcriptional regulator -
QAZ22_RS05595 (QAZ22_05595) 1175075..1175926 + 852 WP_278207791.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
QAZ22_RS05600 (QAZ22_05600) 1175923..1176690 + 768 WP_278206012.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
QAZ22_RS05605 (QAZ22_05605) 1176719..1177051 + 333 WP_278206013.1 cupin domain-containing protein -
QAZ22_RS05610 (QAZ22_05610) 1177323..1177949 - 627 WP_278206014.1 LysE family translocator -
QAZ22_RS05615 (QAZ22_05615) 1178073..1178369 + 297 WP_278206015.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QAZ22_RS05620 (QAZ22_05620) 1178377..1178685 + 309 WP_278206016.1 HigA family addiction module antitoxin Antitoxin
QAZ22_RS05625 (QAZ22_05625) 1178821..1180674 + 1854 WP_278206017.1 DNA helicase RecQ -
QAZ22_RS05630 (QAZ22_05630) 1180712..1181605 - 894 WP_278206018.1 DUF1186 domain-containing protein -
QAZ22_RS05635 (QAZ22_05635) 1181939..1183072 + 1134 WP_278206019.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11804.33 Da        Isoelectric Point: 6.8813

>T276283 WP_278206015.1 NZ_CP121355:1178073-1178369 [Mesorhizobium sp. WSM4906]
MILGFRDEWLRAFFVDDAHSRNIPSDLELRLFRKLQMIDDAMTDPDLRVPPSNHFEKLRGNLEGFHSIRVNKQWRLVFRW
DGRRGEASDVYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11702.64 Da        Isoelectric Point: 11.3562

>AT276283 WP_278206016.1 NZ_CP121355:1178377-1178685 [Mesorhizobium sp. WSM4906]
MLATKRRPVTIGEILVEEFMRPMGLTQAALAEAMGVQRKHVNELCNNRRNVTAPTALILARVFGNSPEFWLNVQRRSDLW
EAMHDPKERERIKRARPLPNAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References