Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2695340..2695862 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P1839_RS12980 Protein ID WP_000221343.1
Coordinates 2695578..2695862 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag P1839_RS12975 Protein ID WP_000885424.1
Coordinates 2695340..2695588 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS12950 (2690556) 2690556..2692021 + 1466 Protein_2510 hypothetical protein -
P1839_RS12955 (2692829) 2692829..2693543 + 715 Protein_2511 helix-turn-helix domain-containing protein -
P1839_RS12960 (2693599) 2693599..2694507 - 909 WP_010989018.1 hypothetical protein -
P1839_RS12965 (2694650) 2694650..2694983 - 334 Protein_2513 DUF1493 family protein -
P1839_RS12970 (2694973) 2694973..2695188 - 216 WP_000206207.1 hypothetical protein -
P1839_RS12975 (2695340) 2695340..2695588 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1839_RS12980 (2695578) 2695578..2695862 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1839_RS12985 (2696033) 2696033..2696422 + 390 WP_000194089.1 RidA family protein -
P1839_RS12990 (2696474) 2696474..2697553 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P1839_RS12995 (2697746) 2697746..2698234 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
P1839_RS13000 (2698279) 2698279..2699787 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2690559..2702644 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T276261 WP_000221343.1 NZ_CP121298:2695578-2695862 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT276261 WP_000885424.1 NZ_CP121298:2695340-2695588 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References