Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 157216..157818 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1839_RS00735 Protein ID WP_001159630.1
Coordinates 157507..157818 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1839_RS00730 Protein ID WP_000362050.1
Coordinates 157216..157506 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS00715 (154709) 154709..155611 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P1839_RS00720 (155608) 155608..156243 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1839_RS00725 (156240) 156240..157169 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P1839_RS00730 (157216) 157216..157506 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1839_RS00735 (157507) 157507..157818 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1839_RS00740 (158036) 158036..158965 + 930 WP_001127703.1 alpha/beta hydrolase -
P1839_RS00745 (159051) 159051..159362 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1839_RS00750 (159359) 159359..159805 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P1839_RS00755 (159820) 159820..160761 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1839_RS00760 (160806) 160806..161243 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
P1839_RS00765 (161253) 161253..162020 - 768 Protein_139 virulence factor BrkB family protein -
P1839_RS00770 (162107) 162107..162706 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T276250 WP_001159630.1 NZ_CP121298:c157818-157507 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT276250 WP_000362050.1 NZ_CP121298:c157506-157216 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References