Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1359107..1359709 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P1838_RS06480 Protein ID WP_001159630.1
Coordinates 1359398..1359709 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P1838_RS06475 Protein ID WP_000362050.1
Coordinates 1359107..1359397 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS06460 (1356599) 1356599..1357502 + 904 Protein_1246 formate dehydrogenase subunit beta -
P1838_RS06465 (1357499) 1357499..1358134 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P1838_RS06470 (1358131) 1358131..1359060 + 930 WP_076737574.1 formate dehydrogenase accessory protein FdhE -
P1838_RS06475 (1359107) 1359107..1359397 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P1838_RS06480 (1359398) 1359398..1359709 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P1838_RS06485 (1359927) 1359927..1360856 + 930 WP_076737573.1 alpha/beta hydrolase -
P1838_RS06490 (1360942) 1360942..1361253 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P1838_RS06495 (1361250) 1361250..1361696 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
P1838_RS06500 (1361711) 1361711..1362652 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P1838_RS06505 (1362697) 1362697..1363134 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
P1838_RS06510 (1363131) 1363131..1364003 - 873 WP_000921423.1 virulence factor BrkB family protein -
P1838_RS06515 (1363997) 1363997..1364596 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T276228 WP_001159630.1 NZ_CP121296:c1359709-1359398 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT276228 WP_000362050.1 NZ_CP121296:c1359397-1359107 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References