Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3910234..3910836 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag P9N54_RS18815 Protein ID WP_000897305.1
Coordinates 3910234..3910545 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P9N54_RS18820 Protein ID WP_000356397.1
Coordinates 3910546..3910836 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS18785 (3905264) 3905264..3906049 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
P9N54_RS18790 (3906148) 3906148..3906747 + 600 WP_001295269.1 glucose-1-phosphatase -
P9N54_RS18795 (3906741) 3906741..3907613 + 873 WP_000920762.1 virulence factor BrkB family protein -
P9N54_RS18800 (3907610) 3907610..3908047 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
P9N54_RS18805 (3908092) 3908092..3909033 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
P9N54_RS18810 (3909097) 3909097..3910005 - 909 WP_001162704.1 alpha/beta hydrolase -
P9N54_RS18815 (3910234) 3910234..3910545 + 312 WP_000897305.1 hypothetical protein Toxin
P9N54_RS18820 (3910546) 3910546..3910836 + 291 WP_000356397.1 NadS family protein Antitoxin
P9N54_RS18825 (3911441) 3911441..3911659 + 219 WP_001315930.1 CopG family transcriptional regulator -
P9N54_RS18830 (3911879) 3911879..3912121 + 243 WP_001087409.1 protein YiiF -
P9N54_RS18835 (3912451) 3912451..3913380 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
P9N54_RS18840 (3913377) 3913377..3914012 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
P9N54_RS18845 (3914009) 3914009..3914911 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T276207 WP_000897305.1 NZ_CP121294:3910234-3910545 [Escherichia coli O155:H21]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT276207 WP_000356397.1 NZ_CP121294:3910546-3910836 [Escherichia coli O155:H21]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References