Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3553468..3554143 Replicon chromosome
Accession NZ_CP121269
Organism Enterobacter hormaechei subsp. xiangfangensis strain F81Y

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P9J39_RS16825 Protein ID WP_278106349.1
Coordinates 3553468..3553767 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag P9J39_RS16830 Protein ID WP_015571639.1
Coordinates 3553778..3554143 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J39_RS16815 (P9J39_16815) 3549845..3552037 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
P9J39_RS16820 (P9J39_16820) 3552018..3553217 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
P9J39_RS16825 (P9J39_16825) 3553468..3553767 + 300 WP_278106349.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9J39_RS16830 (P9J39_16830) 3553778..3554143 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
P9J39_RS16835 (P9J39_16835) 3554170..3555351 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
P9J39_RS16840 (P9J39_16840) 3555372..3556259 - 888 WP_015571641.1 LysR family transcriptional regulator -
P9J39_RS16845 (P9J39_16845) 3556357..3556959 + 603 WP_045340137.1 short chain dehydrogenase -
P9J39_RS16850 (P9J39_16850) 3556956..3557687 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11654.31 Da        Isoelectric Point: 9.3210

>T276169 WP_278106349.1 NZ_CP121269:3553468-3553767 [Enterobacter hormaechei subsp. xiangfangensis]
MINHFWDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT276169 WP_015571639.1 NZ_CP121269:3553778-3554143 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References