Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4686796..4687398 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag P8621_RS22925 Protein ID WP_001159630.1
Coordinates 4687087..4687398 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8621_RS22920 Protein ID WP_000362050.1
Coordinates 4686796..4687086 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS22905 (4684289) 4684289..4685191 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
P8621_RS22910 (4685188) 4685188..4685823 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
P8621_RS22915 (4685820) 4685820..4686749 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
P8621_RS22920 (4686796) 4686796..4687086 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
P8621_RS22925 (4687087) 4687087..4687398 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
P8621_RS22930 (4687616) 4687616..4688545 + 930 WP_001127703.1 alpha/beta hydrolase -
P8621_RS22935 (4688631) 4688631..4688942 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
P8621_RS22940 (4688939) 4688939..4689385 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
P8621_RS22945 (4689400) 4689400..4690341 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
P8621_RS22950 (4690386) 4690386..4690823 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
P8621_RS22955 (4690820) 4690820..4691692 - 873 WP_000921427.1 virulence factor BrkB family protein -
P8621_RS22960 (4691686) 4691686..4692285 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T276155 WP_001159630.1 NZ_CP121262:c4687398-4687087 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT276155 WP_000362050.1 NZ_CP121262:c4687086-4686796 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References