27615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2727860..2728362 Replicon chromosome
Accession NC_017660
Organism Escherichia coli KO11FL

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KO11_RS13335 Protein ID WP_000767829.1
Coordinates 2728108..2728362 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KO11_RS13330 Protein ID WP_001259255.1
Coordinates 2727860..2728111 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KO11_RS13310 2723038..2724105 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KO11_RS13315 2724105..2725175 - 1071 WP_000108957.1 histidinol-phosphate transaminase -
KO11_RS13320 2725172..2726476 - 1305 WP_001349967.1 histidinol dehydrogenase -
KO11_RS13325 2726482..2727381 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
KO11_RS25840 2727527..2727577 - 51 WP_001364200.1 his operon leader peptide -
KO11_RS13330 2727860..2728111 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KO11_RS13335 2728108..2728362 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KO11_RS13340 2728445..2729269 + 825 WP_000754749.1 SDR family oxidoreductase -
KO11_RS13345 2729315..2730244 + 930 WP_000803351.1 LysR family transcriptional regulator -
KO11_RS27765 2730459..2730521 + 63 WP_010723108.1 membrane protein YoeI -
KO11_RS13350 2730511..2731869 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KO11_RS13355 2732048..2733106 + 1059 WP_000492346.1 transport protein YeeE -
KO11_RS13360 2733120..2733347 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T27615 WP_000767829.1 NC_017660:2728108-2728362 [Escherichia coli KO11FL]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T27615 NC_017660:2728108-2728362 [Escherichia coli KO11FL]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT27615 WP_001259255.1 NC_017660:2727860-2728111 [Escherichia coli KO11FL]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT27615 NC_017660:2727860-2728111 [Escherichia coli KO11FL]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References