276148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2415296..2415818 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P8621_RS11835 Protein ID WP_000221343.1
Coordinates 2415534..2415818 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag P8621_RS11830 Protein ID WP_000885424.1
Coordinates 2415296..2415544 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS11805 (2410512) 2410512..2411978 + 1467 WP_000987828.1 hypothetical protein -
P8621_RS11810 (2412786) 2412786..2413500 + 715 Protein_2307 helix-turn-helix domain-containing protein -
P8621_RS11815 (2413556) 2413556..2414464 - 909 WP_010989018.1 hypothetical protein -
P8621_RS11820 (2414607) 2414607..2414939 - 333 WP_000253154.1 DUF1493 family protein -
P8621_RS11825 (2414929) 2414929..2415144 - 216 WP_000206207.1 hypothetical protein -
P8621_RS11830 (2415296) 2415296..2415544 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P8621_RS11835 (2415534) 2415534..2415818 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8621_RS11840 (2415989) 2415989..2416378 + 390 WP_000194089.1 RidA family protein -
P8621_RS11845 (2416430) 2416430..2417509 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P8621_RS11850 (2417702) 2417702..2418190 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
P8621_RS11855 (2418235) 2418235..2419743 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2410515..2422600 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T276148 WP_000221343.1 NZ_CP121262:2415534-2415818 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT276148 WP_000885424.1 NZ_CP121262:2415296-2415544 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References