Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 736708..737366 Replicon chromosome
Accession NZ_CP121247
Organism Arcanobacterium wilhelmae strain DSM 102162

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag P8A24_RS03230 Protein ID WP_278059682.1
Coordinates 737013..737366 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag P8A24_RS03225 Protein ID WP_278059680.1
Coordinates 736708..737016 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8A24_RS03205 (P8A24_03205) 732736..733749 - 1014 WP_278059673.1 polysaccharide deacetylase family protein -
P8A24_RS03210 (P8A24_03210) 733889..734746 - 858 WP_278059675.1 glutaminyl-peptide cyclotransferase -
P8A24_RS03215 (P8A24_03215) 734983..735234 - 252 WP_278059676.1 type B 50S ribosomal protein L31 -
P8A24_RS03220 (P8A24_03220) 735483..736706 + 1224 WP_278059678.1 amidohydrolase -
P8A24_RS03225 (P8A24_03225) 736708..737016 - 309 WP_278059680.1 helix-turn-helix transcriptional regulator Antitoxin
P8A24_RS03230 (P8A24_03230) 737013..737366 - 354 WP_278059682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8A24_RS03235 (P8A24_03235) 737421..738269 - 849 WP_278059684.1 M15 family metallopeptidase -
P8A24_RS03240 (P8A24_03240) 738368..739354 - 987 WP_278059686.1 PRD domain-containing protein -
P8A24_RS03245 (P8A24_03245) 739606..741636 - 2031 WP_278059688.1 glucose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13370.42 Da        Isoelectric Point: 10.4050

>T276130 WP_278059682.1 NZ_CP121247:c737366-737013 [Arcanobacterium wilhelmae]
VWEIDVEPVADWLSRLDPSSSVQVIAALELLREHGPSLGRPLVDTISGSRHKNMKELWPGSSGRSKIRLLFIFDPNRRAI
ILIAGDKSGQWTKWYKTNIPIADDRYDLHLKQLKRGK

Download         Length: 354 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11505.18 Da        Isoelectric Point: 7.2060

>AT276130 WP_278059680.1 NZ_CP121247:c737016-736708 [Arcanobacterium wilhelmae]
MMALLLEDFLRDRPVDRHAIDEAKENMMAQVRAHRLRELRESAGLTQSDVAQRLGVSQRQVSKIERGEIETTKLGTIRNY
LSAIGGSLSLEFIQGDIRVQVA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References