Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 52186..52867 Replicon chromosome
Accession NZ_CP121247
Organism Arcanobacterium wilhelmae strain DSM 102162

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag P8A24_RS00280 Protein ID WP_278058550.1
Coordinates 52508..52867 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P8A24_RS00275 Protein ID WP_278058549.1
Coordinates 52186..52494 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8A24_RS00255 (P8A24_00255) 48713..50005 + 1293 WP_278058541.1 hypothetical protein -
P8A24_RS00260 (P8A24_00260) 50156..50839 + 684 WP_278058543.1 hydrolase -
P8A24_RS00265 (P8A24_00265) 50999..51331 + 333 WP_278058545.1 TM2 domain-containing protein -
P8A24_RS00270 (P8A24_00270) 51459..52082 - 624 WP_278058547.1 MBL fold metallo-hydrolase -
P8A24_RS00275 (P8A24_00275) 52186..52494 - 309 WP_278058549.1 XRE family transcriptional regulator Antitoxin
P8A24_RS00280 (P8A24_00280) 52508..52867 - 360 WP_278058550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8A24_RS00285 (P8A24_00285) 53042..54052 - 1011 WP_278058551.1 type I glyceraldehyde-3-phosphate dehydrogenase -
P8A24_RS00290 (P8A24_00290) 54271..55836 - 1566 WP_278058553.1 alkyl hydroperoxide reductase subunit F -
P8A24_RS00295 (P8A24_00295) 55903..56466 - 564 WP_278058555.1 alkyl hydroperoxide reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13828.84 Da        Isoelectric Point: 6.4879

>T276128 WP_278058550.1 NZ_CP121247:c52867-52508 [Arcanobacterium wilhelmae]
MWEIILMKQVEDWLLNLTDDDYDLVAAAITRLETAGPALGRPTADHIKASRHHNMKELRPGSRGRSKIRILFAFDPHRQA
VLLIAGDKADKWSEWYKTNIPRADALFDEWLLQLKTYEE

Download         Length: 360 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11319.90 Da        Isoelectric Point: 6.3623

>AT276128 WP_278058549.1 NZ_CP121247:c52494-52186 [Arcanobacterium wilhelmae]
METTSWKDMKAQRQPRPERVAELVQQMEAEERAYSLRQIRESLGVTQSEVAQRMNLTQPTISALEKGELGRSGLDTLRAY
VTALGGAVEVVATFGNQKLILG

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References