276121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2655015..2655278 Replicon chromosome
Accession NZ_CP121233
Organism Enterococcus faecalis strain SVJ-EF01

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag ORD27_RS13005 Protein ID WP_002392696.1
Coordinates 2655135..2655278 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2655015..2655202 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORD27_RS12990 (2652749) 2652749..2653399 + 651 WP_085443093.1 beta-phosphoglucomutase -
ORD27_RS12995 (2653861) 2653861..2654454 + 594 WP_010706987.1 PBECR4 domain-containing protein -
- (2654577) 2654577..2654762 + 186 NuclAT_6 - -
ORD27_RS13000 (2654695) 2654695..2654838 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2655015) 2655015..2655202 + 188 NuclAT_5 - Antitoxin
ORD27_RS13005 (2655135) 2655135..2655278 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
ORD27_RS13010 (2655511) 2655511..2656482 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
ORD27_RS13015 (2656657) 2656657..2657094 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
ORD27_RS13020 (2657227) 2657227..2657781 - 555 WP_002354869.1 Maf family protein -
ORD27_RS13025 (2657806) 2657806..2659938 - 2133 WP_010713705.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T276121 WP_002392696.1 NZ_CP121233:c2655278-2655135 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 188 bp

>AT276121 NZ_CP121233:2655015-2655202 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References