Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2807215..2807833 Replicon chromosome
Accession NZ_CP121223
Organism Shigella flexneri 2a strain Sflex 21-42

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5F89_RS15785 Protein ID WP_001291435.1
Coordinates 2807215..2807433 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag P5F89_RS15790 Protein ID WP_000344797.1
Coordinates 2807459..2807833 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5F89_RS15755 (2803107) 2803107..2803418 - 312 WP_000409911.1 MGMT family protein -
P5F89_RS15765 (2803797) 2803797..2804150 + 354 WP_000878140.1 DUF1428 domain-containing protein -
P5F89_RS15770 (2804192) 2804192..2805742 - 1551 WP_005098218.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5F89_RS15775 (2805906) 2805906..2806376 - 471 WP_000136192.1 YlaC family protein -
P5F89_RS15780 (2806492) 2806492..2807043 - 552 Protein_2663 maltose O-acetyltransferase -
P5F89_RS15785 (2807215) 2807215..2807433 - 219 WP_001291435.1 HHA domain-containing protein Toxin
P5F89_RS15790 (2807459) 2807459..2807833 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
P5F89_RS15795 (2808379) 2808379..2811528 - 3150 WP_001132484.1 efflux RND transporter permease AcrB -
P5F89_RS15800 (2811551) 2811551..2812744 - 1194 WP_011069267.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2801749..2803077 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276097 WP_001291435.1 NZ_CP121223:c2807433-2807215 [Shigella flexneri 2a]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT276097 WP_000344797.1 NZ_CP121223:c2807833-2807459 [Shigella flexneri 2a]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References