Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 2770033..2770877 Replicon chromosome
Accession NZ_CP121223
Organism Shigella flexneri 2a strain Sflex 21-42

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag P5F89_RS15590 Protein ID WP_014532172.1
Coordinates 2770033..2770494 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag P5F89_RS15595 Protein ID WP_005053053.1
Coordinates 2770566..2770877 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5F89_RS15575 (2765201) 2765201..2766931 - 1731 WP_000645013.1 hypothetical protein -
P5F89_RS15580 (2766984) 2766984..2769137 - 2154 WP_005060811.1 SEL1-like repeat protein -
P5F89_RS15585 (2769288) 2769288..2769985 + 698 WP_252965753.1 IS1 family transposase -
P5F89_RS15590 (2770033) 2770033..2770494 - 462 WP_014532172.1 GNAT family N-acetyltransferase Toxin
P5F89_RS15595 (2770566) 2770566..2770877 - 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
P5F89_RS15600 (2771061) 2771061..2771951 - 891 WP_000971346.1 heme o synthase -
P5F89_RS15605 (2771963) 2771963..2772292 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
P5F89_RS15610 (2772292) 2772292..2772906 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
P5F89_RS15615 (2772896) 2772896..2774887 - 1992 Protein_2631 cytochrome o ubiquinol oxidase subunit I -
P5F89_RS15620 (2774909) 2774909..2775406 - 498 Protein_2632 COX aromatic rich motif-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2769482..2769985 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T276096 WP_014532172.1 NZ_CP121223:c2770494-2770033 [Shigella flexneri 2a]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT276096 WP_005053053.1 NZ_CP121223:c2770877-2770566 [Shigella flexneri 2a]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References